Unrelated donor haemopoietic stem-cell transplantation: ATG or not?
نویسندگان
چکیده
منابع مشابه
Unrelated donor haemopoietic stem-cell transplantation: ATG or not?
Chronic graft-versus-host disease (GVHD) is a multisystemic syndrome involving tissue inflammation and fibrosis that shares many clinical manifestations with autoimmune diseases such as systemic lupus erythematous or systemic sclerosis. Despite being associated with lower relapse rates, chronic GVHD is the main cause of late mortality after unrelated allogeneic haemopoietic stem-cell transplant...
متن کاملOutcomes from unrelated donor hematopoietic stem cell transplantation.
BACKGROUND Allogeneic hematopoietic cell transplantation (HCT) offers a curative treatment option for management of a variety of hematologic malignancies. While sibling donors have been the gold standard for adult patients in need of an HCT, not all patients have a suitable family donor. The availability of unrelated volunteer donor registries and alternative stem cell sources has expanded the ...
متن کاملUnrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood?
Hematopoietic cell transplantation (HCT) can be curative for selected malignant and nonmalignant diseases.1-13 However, utilization and success of HCT are limited by several obstacles, primarily related to the importance of donor-recipient genetic match for favorable outcomes. While in most settings, best results are offered by human leukocyte antigen (HLA)14,15–identical sibling transplantatio...
متن کاملExcellent survival after sibling or unrelated donor stem cell transplantation for chronic granulomatous disease.
BACKGROUND Matched related donor (MRD) hematopoietic stem cell transplantation (HSCT) is a successful treatment for chronic granulomatous disease (CGD), but the safety and efficacy of HSCT from unrelated donors is less certain. OBJECTIVE We evaluated the outcomes and overall survival in patients with CGD after HSCT. METHODS We report the outcomes for 11 children undergoing HSCT from an MRD ...
متن کاملUnrelated donor stem cell transplantation: the role of the National Marrow Donor Program.
Since its founding in 1986, the NMDP has facilitated more than 16,000 transplants for patients with blood disorders such as leukemia and aplastic anemia, as well as immune system disorders and genetic disorders. The donors who provided the blood stem cells for these transplants came from the NMDP Registry, the world's largest and most diverse registry of potential blood stem cell donors. Initia...
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ژورنال
عنوان ژورنال: The Lancet Haematology
سال: 2017
ISSN: 2352-3026
DOI: 10.1016/s2352-3026(17)30064-9